iPSCs Offer a New Look at GATA1-Trisomy 21 Cooperation.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 27152438.
- Also identified by DOI 10.1016/j.stem.2016.04.007.
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Abstract
GATA1 mutations and trisomy 21 are inextricably linked in the neonatal leukemia of children with Down syndrome (DS). A recent report by Banno et al. (2016) sheds new light on the mechanism of the synergy between these genetic alterations by modeling hematopoietic abnormalities with patient-derived induced pluripotent stem cells.
Medical subject headings
- Down Syndrome
- GATA1 Transcription Factor