TGF-β Pathway Inhibition Signals New Hope for Fanconi Anemia.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27152440.
- Also identified by DOI 10.1016/j.stem.2016.04.008.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
An improved understanding of the bone marrow failure (BMF) mechanisms in Fanconi anemia (FA) may improve current therapeutic strategies. Zhang et al. identify hyperactive TGF-β signaling as an underlying cause of BMF in FA mice and patient cells, whose inhibition promotes DNA repair and hematopoietic stem and progenitor cell survival.
Medical subject headings
- Fanconi Anemia
- Signal Transduction
- Transforming Growth Factor beta