Induced Pluripotent Stem Cells Meet Genome Editing.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27152442.
- Also identified by DOI 10.1016/j.stem.2016.04.013 and PMC identifier 4871596.
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Abstract
It is extremely rare for a single experiment to be so impactful and timely that it shapes and forecasts the experiments of the next decade. Here, we review how two such experiments-the generation of human induced pluripotent stem cells (iPSCs) and the development of CRISPR/Cas9 technology-have fundamentally reshaped our approach to biomedical research, stem cell biology, and human genetics. We will also highlight the previous knowledge that iPSC and CRISPR/Cas9 technologies were built on as this groundwork demonstrated the need for solutions and the benefits that these technologies provided and set the stage for their success.
Medical subject headings
- Gene Editing
- Genome, Human
- Induced Pluripotent Stem Cells