Thoughts on Obesity and Brain Glucose.

Heneka, Michael T; Nicotera, Pierluigi · Cell · 2016

review · Level V

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Abstract

Homeostatic control of brain metabolism is essential for neuronal activity. Jais et al., (2016) report that reduced brain glucose uptake elicited by a high-fat diet self-corrects by the recruitment of peripheral, VEGF-producing macrophages to the blood-brain barrier. Their findings further suggest that restoring brain glucose availability might help protect from cognitive impairment in Alzheimer's disease.

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