False Positive Lyme Disease IgM Immunoblots in Children.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 27157898.
- Also identified by DOI 10.1016/j.jpeds.2016.04.004 and PMC identifier 4925275.
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Abstract
In our cross-sectional sample of 7289 serologic tests for Lyme disease, we identified 167 instances of a positive IgM immunoblot but a negative IgG immunoblot test result. Considering that only 71% (95% CI 64%-78%) of patients had Lyme disease, a positive IgM immunoblot alone should be interpreted with caution to avoid over-diagnosis of Lyme disease.
Medical subject headings
- Immunoblotting
- Immunoglobulin M
- Lyme Disease