Fatty Acid-Induced T Cell Loss Greases Liver Carcinogenesis.
Level V
Where this comes from
- Record sourced from PubMed, PMID 27166937.
- Also identified by DOI 10.1016/j.cmet.2016.04.018.
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Abstract
A new study has added loss of CD4(+) T cells caused by aberrant lipid metabolism to the list of mechanisms promoting nonalcoholic steatohepatitis progression to liver cancer (Ma et al., 2016). Exposure of CD4(+) T cells to free linoleic acid causes their ROS-mediated depletion, thereby favoring liver cancer growth.
Medical subject headings
- Carcinogenesis
- Fatty Acids
- Liver
- T-Lymphocytes