Emperor's new clothes: Is particle disease really infected particle disease?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27175824.
- Also identified by DOI 10.1002/jor.23292 and PMC identifier 5529039.
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Abstract
Aseptic loosening remains the most significant long-term complication of total hip replacement. The current paradigm points to an inflammatory response to wear particles as its main trigger. Recently, there have been increasing numbers of positive bacterial isolates reported among patients with clinically absent infection. This paper reviews existing evidence on possible involvement of bacteria and microbial-associated molecular patterns in the pathology of so-called "aseptic loosening." © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1497-1504, 2016.
Medical subject headings
- Arthroplasty, Replacement, Hip
- Bacterial Infections
- Prosthesis Failure
Anatomy
- hip