Enhanced Lineage-Specific Differentiation Efficiency of Human Induced Pluripotent Stem Cells by Engineering Colony Dimensionality Using Electrospun Scaffolds.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27187808.
- Also identified by DOI 10.1002/adhm.201600141.
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Abstract
Electrospun scaffolds with varied stiffness promote distinct colony morphology of human induced pluripotent stem cells, which affects their subsequent differentiation. On soft scaffolds, induced pluripotent stem cells develop 3D colonies due to the pliability of the electrospun fibrous networks, leading to greater differentiation tendency to ectodermal lineage.
Medical subject headings
- Cell Differentiation
- Induced Pluripotent Stem Cells
- Tissue Scaffolds