Genetic Evolution of a Helicobacter pylori Acid-Sensing Histidine Kinase and Gastric Disease.
basic_science · Level V
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- Record sourced from PubMed, PMID 27190191.
- Also identified by DOI 10.1093/infdis/jiw189 and PMC identifier 4957439.
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Abstract
Helicobacter pylori is the strongest risk factor for gastric adenocarcinoma, which develops within a hypochlorhydric environment. We sequentially isolated H. pylori (strain J99) from a patient who developed corpus-predominant gastritis and hypochlorhydia over a 6-year interval. Archival J99 survived significantly better under acidic conditions than recent J99 strains. H. pylori arsRS encodes a 2-component system critical for stress responses; recent J99 isolates harbored 2 nonsynonymous arsS mutations, and arsS inactivation abolished acid survival. In vivo, acid-resistant archival, but not recent J99, successfully colonized high-acid-secreting rodents. Thus, genetic evolution of arsS may influence progression to hypochlorhydia and gastric cancer.
Medical subject headings
- Achlorhydria
- Evolution, Molecular
- Gastritis
- Helicobacter Infections
- Helicobacter pylori
- Histidine Kinase