Reproducible pharmacogenomic profiling of cancer cell line panels.
basic_science · Level V
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- Record sourced from PubMed, PMID 27193678.
- Also identified by DOI 10.1038/nature17987.
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Abstract
The use of large-scale genomic and drug response screening of cancer cell lines depends crucially on the reproducibility of results. Here we consider two previously published screens, plus a later critique of these studies. Using independent data, we show that consistency is achievable, and provide a systematic description of the best laboratory and analysis practices for future studies.