Tension-Time Integrals and Genetic Cardiomyopathy: The Force Is with You.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27203107.
- Also identified by DOI 10.1016/j.cell.2016.04.036.
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Abstract
Hundreds of different mutations in genes encoding a few dozen sarcomeric proteins cause two reciprocal human disease phenotypes, hypertrophic or dilated cardiomyopathy. How molecular dysfunction evokes different patterns of cardiac remodeling is unclear. Davis et al. describe a biophysical metric of cardiomyocyte function, the force-time integral, which predicts disease phenotype.
Medical subject headings
- Cardiomyopathy, Dilated
- Mutation