The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27203110.
- Also identified by DOI 10.1016/j.cell.2016.05.004 and PMC identifier 4878688.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We here attempt to achieve an integrated understanding of the structure and dynamics of a number of higher-order assemblies, including amyloids, various kinds of signalosomes, and cellular granules. We propose that the synergy between folded domains, linear motifs, and intrinsically disordered regions regulates the formation and intrinsic fuzziness of all higher-order assemblies, creating a structural and dynamic continuum. We describe how such regulatory mechanisms could be influenced under pathological conditions.
Medical subject headings
- Organelles