miR-135a Inhibits the Invasion of Cancer Cells via Suppression of ERRα.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27227989.
- Also identified by DOI 10.1371/journal.pone.0156445 and PMC identifier 4881992.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
MicroRNA-135a (miR-135a) down-modulates parameters of cancer progression and its expression is decreased in metastatic breast cancers (as compared to non-metastatic tumors) as well as in prostate tumors relative to normal tissue. These expression and activity patterns are opposite to those of the Estrogen-Related Receptor α (ERRα), an orphan member of the nuclear receptor family. Indeed high expression of ERRα correlates with poor prognosis in breast and prostate cancers, and the receptor promotes various traits of cancer aggressiveness including cell invasion. Here we show that miR-135a down-regulates the expression of ERRα through specific sequences of its 3'UTR. As a consequence miR-135a also reduces the expression of downstream targets of ERRα. miR-135a also decreases cell invasive potential in an ERRα-dependent manner. Our results suggest that the decreased expression of miR-135a in metastatic tumors leads to elevated ERRα expression, resulting in increased cell invasion capacities.
Medical subject headings
- Breast Neoplasms
- Gene Expression Regulation, Neoplastic
- MicroRNAs
- Neoplasm Proteins
- Prostatic Neoplasms
- RNA, Neoplasm
- Receptors, Estrogen