Turning the corner in fertility: high DNA integrity of boundary-following sperm.
Where this comes from
- Record sourced from PubMed, PMID 27241827.
- Also identified by DOI 10.1039/c6lc00490c.
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Abstract
We present a passive microfluidic sperm selection strategy that collects motile sperm based on their preference to follow boundaries and turn corners. Clinical assessment of selected human sperm from the device revealed a strong correlation between high DNA integrity and the tendency for sperm to follow boundaries. Human sperm with preference to follow boundaries on the left- or right-hand sides have higher (>51%) DNA integrity than straight swimmers and significantly higher (>67%) DNA integrity than sperm in raw semen. Boundary following behaviour offers a strategy to selecting sperm with the highest DNA integrity to improve the success rate of assisted reproduction.
Medical subject headings
- Cell Separation
- Sperm Motility
- Spermatozoa