Phospholipid End-Capped Acid-Degradable Polyurethane Micelles for Intracellular Delivery of Cancer Therapeutics.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27245616.
- Also identified by DOI 10.1002/adhm.201600126.
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Abstract
Nanoscale drug carriers fabricated by phospholipid end-capped polyurethane bearing acetal backbones that degrade in acidic conditions are fabricated. These micelles effectively allow drugs to enter the blood circulation, and then disintegrate in acidic endosomes and lysosomes for intelligent delivery of payloads.
Medical subject headings
- Antineoplastic Agents
- Endosomes
- Lysosomes
- Neoplasms
- Phospholipids
- Polyurethanes