Vaccination Against Tuberculosis With Whole-Cell Mycobacterial Vaccines.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27247343.
- Also identified by DOI 10.1093/infdis/jiw228.
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Abstract
Live attenuated and killed whole-cell vaccines (WCVs) offer promising vaccination strategies against tuberculosis. A number of WCV candidates, based on recombinant bacillus Calmette-Guerin (BCG), attenuated Mycobacterium tuberculosis, or related mycobacterial species are in various stages of preclinical or clinical development. In this review, we discuss the vaccine candidates and key factors shaping the development pathway for live and killed WCVs and provide an update on progress.
Medical subject headings
- Mycobacterium
- Tuberculosis
- Tuberculosis Vaccines