Intragenic Locus in Human PIWIL2 Gene Shares Promoter and Enhancer Functions.
Where this comes from
- Record sourced from PubMed, PMID 27248499.
- Also identified by DOI 10.1371/journal.pone.0156454 and PMC identifier 4889060.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Recently, more evidence supporting common nature of promoters and enhancers has been accumulated. In this work, we present data on chromatin modifications and non-polyadenylated transcription characteristic for enhancers as well as results of in vitro luciferase reporter assays suggesting that PIWIL2 alternative promoter in exon 7 also functions as an enhancer for gene PHYHIP located 60Kb upstream. This finding of an intragenic enhancer serving as a promoter for a shorter protein isoform implies broader impact on understanding enhancer-promoter networks in regulation of gene expression.
Medical subject headings
- Argonaute Proteins
- Enhancer Elements, Genetic
- Promoter Regions, Genetic