DYT1 dystonia increases risk taking in humans.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 27249418.
- Also identified by DOI 10.7554/eLife.14155 and PMC identifier 4951192.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
It has been difficult to link synaptic modification to overt behavioral changes. Rodent models of DYT1 dystonia, a motor disorder caused by a single gene mutation, demonstrate increased long-term potentiation and decreased long-term depression in corticostriatal synapses. Computationally, such asymmetric learning predicts risk taking in probabilistic tasks. Here we demonstrate abnormal risk taking in DYT1 dystonia patients, which is correlated with disease severity, thereby supporting striatal plasticity in shaping choice behavior in humans.
Medical subject headings
- Dystonia
- Molecular Chaperones
- Risk-Taking