Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore.

Zhang, Xiao-Dong; Wang, Huasen; Antaris, Alexander L; Li, Lulin; Diao, Shuo; Ma, Rui; Nguyen, Andy; Hong, Guosong et al. · Adv Mater · 2016

basic_science · Level V

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Abstract

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. A bright, renal-excreted, and biocompatible near-infrared II fluorophore for in vivo imaging of TBI is designed. A transient hypoperfusion in the injured cerebral region, followed by fluorophore leakage, is observed. NIR-II fluorophores can provide noninvasive assessment of TBI.

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