Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27256556.
- Also identified by DOI 10.1038/nrn.2016.57 and PMC identifier 5166560.
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Abstract
The dopamine system is unique among the brain's modulatory systems in that it has discrete projections to specific brain regions involved in motor behaviour, cognition and emotion. Dopamine neurons exhibit several activity patterns - including tonic and phasic firing - that are determined by a combination of endogenous pacemaker conductances and regulation by multiple afferent systems. Emerging evidence suggests that disruptions in these regulatory systems may underlie the pathophysiology of several psychiatric disorders, including schizophrenia and depression.
Medical subject headings
- Brain
- Depression
- Depressive Disorder
- Dopamine
- Neurons
- Schizophrenia