Retinas in a Dish Peek into Inherited Retinal Degeneration.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27257755.
- Also identified by DOI 10.1016/j.stem.2016.05.021.
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Abstract
Human retinal degeneration can cause blindness, and the lack of relevant model systems has made identifying underlying mechanisms challenging. Parfitt et al. (2016) generate three-dimensional retinal tissue from patient-derived induced pluripotent stem cells to identify how CEP290 mutations cause retinal degeneration, and show an antisense approach can correct disease-associated phenotypes.
Medical subject headings
- Retina
- Retinal Degeneration