Dangerous Entrapment for NRF2.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27259142.
- Also identified by DOI 10.1016/j.cell.2016.05.061.
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Abstract
Progerin, a mutated lamin A, causes the severe premature-aging syndrome Hutchinson-Gilford progeria (HGPS). Kubben et al. present a driving mechanism for HGPS involving trapping of NRF2 at the nuclear periphery by progerin. This local restriction results in impaired NRF2 signaling and chronic oxidative stress.
Medical subject headings
- Lamin Type A
- Progeria