A TOGgle for Tension at Kinetochores.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27259144.
- Also identified by DOI 10.1016/j.cell.2016.05.060 and PMC identifier 5572793.
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Abstract
Differential stability of kinetochore-microtubule attachments at low versus high tension is critical for accurate chromosome segregation. Miller et al. find that a TOG domain microtubule-binding protein imparts intrinsic tension selectivity to kinetochore-microtubule attachments.
Medical subject headings
- Chromosome Segregation
- Kinetochores