Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27259145.
- Also identified by DOI 10.1016/j.cell.2016.05.053 and PMC identifier 4924582.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Nonsense-mediated mRNA decay (NMD) is a eukaryotic mRNA quality control and regulatory process that plays direct roles in human health and disease. In this Minireview, we discuss how understanding the molecular events that trigger NMD can facilitate strategic targeting of genes via CRISPR/Cas9 technologies and also inform disease diagnostics and treatments.
Medical subject headings
- Genetic Engineering
- Nonsense Mediated mRNA Decay
- Precision Medicine