MIA: non-targeted mass isotopolome analysis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27273671.
- Also identified by DOI 10.1093/bioinformatics/btw317 and PMC identifier 5018370.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
MIA detects and visualizes isotopic enrichment in gas chromatography electron ionization mass spectrometry (GC-EI-MS) datasets in a non-targeted manner. It provides an easy-to-use graphical user interface that allows for visual mass isotopomer distribution analysis across multiple datasets. MIA helps to reveal changes in metabolic fluxes, visualizes metabolic proximity of isotopically enriched compounds and shows the fate of the applied stable isotope labeled tracer. Linux and Windows binaries, documentation, and sample data are freely available for download at http://massisotopolomeanalyzer.lu MIA is a stand-alone application implemented in C ++ and based on Qt5, NTFD and the MetaboliteDetector framework. karsten.hiller@uni.lu.
Medical subject headings
- Mass Spectrometry
- Metabolic Networks and Pathways
- Metabolomics