A BAT-Centric Approach to the Treatment of Diabetes: Turn on the Brain.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27292605.
- Also identified by DOI 10.1016/j.cmet.2016.05.003.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The marked (18)F-flurodeoxyglucose uptake by brown adipose tissue (BAT) enabled its identification in human positron emission tomography imaging studies. In this Perspective, we discuss how glucose extraction by BAT and beige adipose tissue (BeAT) sufficiently impacts on glycemic control. We then present a unique overview of the central circuits modulated by gluco-regulatory hormones, temperature, and glucose itself, which converge on sympathetic preganglionic neurons and whose activation syphon circulating glucose into BAT/BeAT. Targeted stimulation of the sympathetic nervous system at specific nodes to selectively recruit BAT/BeAT may represent a safe and effective means of treating diabetes.
Medical subject headings
- Adipose Tissue, Brown
- Brain
- Diabetes Mellitus