Phase-field model for collective cell migration.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27300922.
- Also identified by DOI 10.1103/PhysRevE.93.052405.
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Abstract
We construct a phase-field model for collective cell migration based on a Ginzburg-Landau free-energy formulation. We model adhesion, surface tension, repulsion, coattraction, and polarization, enabling us to follow the cells' morphologies and the effect of their membranes fluctuations on collective motion. We were able to measure the tissue surface tension as a function of the individual cell cortical tension and adhesion and identify a density threshold for cell-sheet formation.
Medical subject headings
- Cell Movement
- Models, Biological