Proliferating Cells Conserve Nitrogen to Support Growth.

DeBerardinis, Ralph J · Cell Metab · 2016

editorial · Level V

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Abstract

Glutamate provides a large intracellular pool of carbon and nitrogen. Coloff et al. (2016) find that proliferating cells shift from a nitrogen-wasting to a nitrogen-sparing mode of glutamate catabolism, highlighting the exquisite tethering of proliferative signals to metabolism.

Medical subject headings