Opposing Effects of Antidiabetic Interventions on Malignant Growth and Metastasis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 27304493.
- Also identified by DOI 10.1016/j.cmet.2016.05.017.
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Abstract
Type 2 diabetes is associated with increased risk of malignancies, whereas antidiabetic interventions like physical exercise or metformin reduce cancer incidence. A recent publication shows that one diabetes treatment approach, namely incretin-related DPP4 inhibitors, increases metastatic capacity by activating the antioxidant transcription factor NRF2 to decrease reactive oxygen species (ROS) levels.
Medical subject headings
- Hypoglycemic Agents
- Neoplasms