Modulating Cholesterol Homeostasis to Build a Better T Cell.
Level V
Where this comes from
- Record sourced from PubMed, PMID 27304495.
- Also identified by DOI 10.1016/j.cmet.2016.05.015.
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Abstract
There is great interest in discovering targets for in vitro manipulation of autologous T cells that enhance their cytotoxicity against tumor targets as a potent cancer immunotherapy. In a recent Nature paper, Xu and colleagues reveal new insights into the link between cellular cholesterol metabolism and CD8 T cell functions.
Medical subject headings
- CD8-Positive T-Lymphocytes
- Cholesterol
- Homeostasis