A Ribosomal Perspective on Proteostasis and Aging.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27304502.
- Also identified by DOI 10.1016/j.cmet.2016.05.013.
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Abstract
As the first and most direct process influencing the proteostasis capacity of a cell, regulation of translation influences lifespan across taxa. Here we highlight some of the newly discovered means by which translational regulation affects cellular proteostasis, with a focus on mechanisms that may ultimately impinge upon the aging process.
Medical subject headings
- Aging
- Proteins
- Ribosomes