Metformin as a Tool to Target Aging.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27304507.
- Also identified by DOI 10.1016/j.cmet.2016.05.011 and PMC identifier 5943638.
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Abstract
Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs.
Medical subject headings
- Aging
- Metformin