Sliding Hydrogels with Mobile Molecular Ligands and Crosslinks as 3D Stem Cell Niche.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27305637.
- Also identified by DOI 10.1002/adma.201601484 and PMC identifier 5127628.
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Abstract
The development of a sliding hydrogel with mobile crosslinks and biochemical ligands as a 3D stem cell niche is reported. The molecular mobility of this sliding hydrogel allows stem cells to reorganize the surrounding ligands and change their morphology in 3D. Without changing matrix stiffness, sliding hydrogels support efficient stem cell differentiation toward multiple lineages including adipogenesis, chondrogenesis, and osteogenesis.
Medical subject headings
- Cross-Linking Reagents
- Hydrogels
- Mesenchymal Stem Cells
- Stem Cell Niche