Toward Community Standards and Software for Whole-Cell Modeling.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 27305665.
- Also identified by DOI 10.1109/TBME.2016.2560762 and PMC identifier 5451320.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Whole-cell (WC) modeling is a promising tool for biological research, bioengineering, and medicine. However, substantial work remains to create accurate comprehensive models of complex cells. We organized the 2015 Whole-Cell Modeling Summer School to teach WC modeling and evaluate the need for new WC modeling standards and software by recoding a recently published WC model in the Systems Biology Markup Language. Our analysis revealed several challenges to representing WC models using the current standards. We, therefore, propose several new WC modeling standards, software, and databases. We anticipate that these new standards and software will enable more comprehensive models.
Medical subject headings
- Computer Simulation
- Models, Biological
- Software
- Systems Biology