Antibiotics, birth mode, and diet shape microbiome maturation during early life.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 27306664.
- Also identified by DOI 10.1126/scitranslmed.aad7121 and PMC identifier 5308924.
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Abstract
Early childhood is a critical stage for the foundation and development of both the microbiome and host. Early-life antibiotic exposures, cesarean section, and formula feeding could disrupt microbiome establishment and adversely affect health later in life. We profiled microbial development during the first 2 years of life in a cohort of 43 U.S. infants and identified multiple disturbances associated with antibiotic exposures, cesarean section, and formula feeding. These exposures contributed to altered establishment of maternal bacteria, delayed microbiome development, and altered α-diversity. These findings illustrate the complexity of early-life microbiome development and its sensitivity to perturbation.
Medical subject headings
- Anti-Bacterial Agents
- Delivery, Obstetric
- Diet
- Gastrointestinal Microbiome