18F-Fluoroestradiol PET: Current Status and Potential Future Clinical Applications.
review · Level V
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- Record sourced from PubMed, PMID 27307345.
- Also identified by DOI 10.2967/jnumed.116.175596.
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Abstract
Estrogen receptor (ER) expression in breast cancer is associated with a more favorable prognosis and is necessary for a response to endocrine therapies. Traditionally, ER expression is assessed by in vitro assays on biopsied tumor tissue. However, recent advances have allowed in vivo evaluation of ER expression with (18)F-fluoroestradiol ((18)F-FES) PET. Clinical studies have demonstrated the use of (18)F-FES PET as a method for quantifying in vivo ER expression and have explored its potential as a predictive assay and method of assessing in vivo pharmacodynamic response to endocrine therapy. This review outlines the biology and pharmacokinetics of (18)F-FES, highlights the current experience with (18)F-FES in patient studies on breast cancer and other diseases, and discusses potential clinical applications and the possible future clinical use of (18)F-FES PET.
Medical subject headings
- Breast Neoplasms
- Estradiol
- Molecular Imaging
- Positron-Emission Tomography
- Receptors, Estrogen