Longterm Retention Rate and Risk Factors for Adalimumab Discontinuation Due To Efficacy and Safety in Japanese Patients with Rheumatoid Arthritis: An Observational Cohort Study.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 27307531.
- Also identified by DOI 10.3899/jrheum.151006.
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Abstract
To evaluate the rates of retention and discontinuation of adalimumab (ADA) due to efficacy and safety in Japanese patients with rheumatoid arthritis (RA). All patients with RA (n = 476) who were treated with ADA in the Tsurumai Biologics Communication Registry were enrolled. The retention rate of ADA was 46% at 5 years. When focusing on insufficient efficacy, previous biologics use and high baseline disease activity were significant risk factors for up to 1 year. Methotrexate (MTX) use was a significantly low risk factor after 1 year of treatment. Concomitant MTX contributes to the longterm efficacy of ADA therapy.
Medical subject headings
- Adalimumab
- Antirheumatic Agents
- Arthritis, Rheumatoid
- Patient Dropouts