Toward Concurrent Testing for Somatic and Germline Variants in Cancer Patients.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 27307597.
- Also identified by DOI 10.1158/1078-0432.CCR-16-1043.
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Abstract
Sequencing for somatic alterations in patients' tumors is being increasingly clinically implemented to detect mutations that may guide therapy. Germline analysis of a cohort of patients undergoing tumor sequencing with matched normal has revealed that a small but significant percentage of these patients have germline variants that confer cancer susceptibility. Clin Cancer Res; 22(16); 3987-8. ©2016 AACRSee related article by Seifert et al., p. 4087.
Medical subject headings
- Genetic Predisposition to Disease
- Genetic Testing
- Germ-Line Mutation
- Mutation
- Neoplasms