Enhanced Precision of Nanoparticle Phototargeting in Vivo at a Safe Irradiance.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27310596.
- Also identified by DOI 10.1021/acs.nanolett.6b01730.
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Abstract
A large proportion of the payload delivered by nanoparticulate therapies is deposited not in the desired target destination but in off-target locations such as the liver and spleen. Here, we demonstrate that phototargeting can improve the specific targeting of nanoparticles to tumors. The combination of efficient triplet-triplet annihilation upconversion (TTA-UC) and Förster resonance energy transfer (FRET) processes allowed in vivo phototargeting at a safe irradiance (200 mW/cm(2)) over a short period (5 min) using green light.
Medical subject headings
- Drug Delivery Systems
- Fluorescence Resonance Energy Transfer
- Light
- Nanoparticles