Neutrophil Extracellular Trap Formation Is Independent of De Novo Gene Expression.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27310721.
- Also identified by DOI 10.1371/journal.pone.0157454 and PMC identifier 4911059.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Neutrophils are essential innate immune cells whose responses are crucial in the clearance of invading pathogens. Neutrophils can respond to infection by releasing neutrophil extracellular traps (NETs). NETs are formed of chromatin and specific granular proteins and are released after execution of a poorly characterized cell death pathway. Here, we show that NET formation induced by PMA or Candida albicans is independent of RNA polymerase II and III-mediated transcription as well as of protein synthesis. Thus, neutrophils contain all the factors required for NET formation when they emerge from the bone marrow as differentiated cells.
Medical subject headings
- Extracellular Traps
- Gene Expression Regulation
- Neutrophils