Intensive glycemic control and the risk of end-stage renal disease: an ADVANCE in the management of diabetes?

Wyatt, Christina M; Cattran, Daniel C · Kidney Int · 2016

rct · Level II

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Abstract

Posttrial follow-up of participants randomized to intensive versus standard glycemic control in the ADVANCE trial has demonstrated a significant benefit of intensive glycemic control on the risk of end-stage renal disease. In a more detailed analysis, intensive glycemic control appears to be of benefit only before the development of clinically evident kidney disease or in patients with documented early-stage chronic kidney disease.

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