Histone deacetylases 6 increases the cyclic adenosine monophosphate level and promotes renal cyst growth.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 27312442.
- Also identified by DOI 10.1016/j.kint.2016.02.044.
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Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by abnormal enhanced cell proliferation and fluid secretion, which are triggered by increased levels of cyclic adenosine monophosphate (cAMP). Cebotaru et al. showed that a HDAC6 inhibitor reduced the cAMP level and inhibited cyst formation in Pkd1 knockout mice, which may become a new potential therapeutic agent for ADPKD. This study also raised several intriguing questions that might advance our understanding of the molecular pathogenesis of ADPKD.
Medical subject headings
- Cells, Cultured
- Epithelial Cells