Renal blood flow and acute kidney injury in septic shock: an arduous conflict that smolders intrarenally?
Level V
Where this comes from
- Record sourced from PubMed, PMID 27312443.
- Also identified by DOI 10.1016/j.kint.2016.03.025.
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Abstract
Sepsis-induced acute kidney injury (SAKI) is traditionally viewed as a process driven by a reduced blood flow and prone to benefit from vasopressive support. In ovine hyperdynamic septic shock, Lankadeva et al. report a significant and flow-independent intrarenal perfusion and oxygenation "mismatch" jeopardizing the renal medulla that was aggravated by norepinephrine. Medullary and urinary oxygenation changed in parallel, suggesting that urinary oxygenation may act as a biomarker to predict SAKI.
Medical subject headings
- Renal Circulation
- Shock, Septic