Sumoylation Inhibits the Growth Suppressive Properties of Ikaros.
Where this comes from
- Record sourced from PubMed, PMID 27315244.
- Also identified by DOI 10.1371/journal.pone.0157767 and PMC identifier 4912065.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The Ikaros transcription factor is a tumor suppressor that is also important for lymphocyte development. How post-translational modifications influence Ikaros function remains partially understood. We show that Ikaros undergoes sumoylation in developing T cells that correspond to mono-, bi- or poly-sumoylation by SUMO1 and/or SUMO2/3 on three lysine residues (K58, K240 and K425). Sumoylation occurs in the nucleus and requires DNA binding by Ikaros. Sumoylated Ikaros is less effective than unsumoylated forms at inhibiting the expansion of murine leukemic cells, and Ikaros sumoylation is abundant in human B-cell acute lymphoblastic leukemic cells, but not in healthy peripheral blood leukocytes. Our results suggest that sumoylation may be important in modulating the tumor suppressor function of Ikaros.
Medical subject headings
- DNA-Binding Proteins
- Ikaros Transcription Factor
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Transcription, Genetic