Colonic Crypts: Safe Haven from Microbial Products.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 27315471.
- Also identified by DOI 10.1016/j.cell.2016.06.003.
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Abstract
The notion that the colon's deep crypt pockets provide a protected location that shields stem cells from potentially toxic substances is widely accepted. In this issue of Cell, Kaiko et al. reveal how a metabolite abundantly produced by the gut microbiota can inhibit stem cell proliferation but is blocked from doing so by crypt architecture.
Medical subject headings
- Colon
- Stem Cells