SnapShot: Mechanosensing Matrix.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27315485.
- Also identified by DOI 10.1016/j.cell.2016.06.002 and PMC identifier 5341690.
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Abstract
Cells sense and respond to properties of their microenvironment that can affect cell morphology, protein levels and localization, gene expression, and even nuclear integrity. Tissue micro-stiffness, largely influenced by extracellular matrix, varies dramatically within an organism and can be a useful parameter to both clarify and organize a wide range of cell and molecular processes, such as genomic changes in cancer.
Medical subject headings
- Biomechanical Phenomena
- Cell Culture Techniques
- Extracellular Matrix