Controllable Self-Assembly of RNA Tetrahedrons with Precise Shape and Size for Cancer Targeting.

Li, Hui; Zhang, Kaiming; Pi, Fengmei; Guo, Sijin; Shlyakhtenko, Luda; Chiu, Wah; Shu, Dan; Guo, Peixuan · Adv Mater · 2016

basic_science · Level V

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Abstract

RNA tetrahedral nanoparticles with two different sizes are successfully assembled by a one-pot bottom-up approach with high efficiency and thermal stability. The reported design principles can be extended to construct higher-order polyhedral RNA architectures for various applications such as targeted cancer imaging and therapy.

Medical subject headings