Skeletal Metabolism, Fracture Risk, and Fracture Outcomes in Type 1 and Type 2 Diabetes.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27329951.
- Also identified by DOI 10.2337/db16-0063 and PMC identifier 4915586.
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Abstract
Fracture risk is significantly increased in both type 1 and type 2 diabetes, and individuals with diabetes experience worse fracture outcomes than normoglycemic individuals. Factors that increase fracture risk include lower bone mass in type 1 diabetes and compromised skeletal quality and strength despite preserved bone density in type 2 diabetes, as well as the effects of comorbidities such as diabetic macro- and microvascular complications. In this Perspective, we assess the developing scientific knowledge regarding the epidemiology and pathophysiology of skeletal fragility in patients with diabetes and the emerging data on the prediction, treatment, and outcomes of fractures in individuals with type 1 and type 2 diabetes.
Medical subject headings
- Bone Density
- Bone and Bones
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Fractures, Bone