Polydopamine Hollow Nanoparticle Functionalized with N-diazeniumdiolates as a Nitric Oxide Delivery Carrier for Antibacterial Therapy.

Park, Dongsik; Kim, Jihoon; Lee, Yeong Mi; Park, Junghong; Kim, Won Jong · Adv Healthc Mater · 2016

basic_science · Level V

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Abstract

A biocompatible nitric oxide (NO) delivery nanoplatform, whose structure is a hollow nanoparticle composed of polydopamine backbone and diazeniumdiolates functional groups, is developed for antibacterial therapy. This platform liberates high NO quantitis and exerts the antibacterial activity with excellent biocompatibility thus being promising for treating bacterial infections.

Medical subject headings