Broad and Temperature Independent Replication Potential of Filoviruses on Cells Derived From Old and New World Bat Species.
basic_science · Level V
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- Record sourced from PubMed, PMID 27354372.
- Also identified by PMC identifier 5050464.
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Abstract
Filoviruses are strongly associated with several species of bats as their natural reservoirs. In this study, we determined the replication potential of all filovirus species: Marburg marburgvirus, Taï Forest ebolavirus, Reston ebolavirus, Sudan ebolavirus, Zaire ebolavirus, and Bundibugyo ebolavirus. Filovirus replication was supported by all cell lines derived from 6 Old and New World bat species: the hammer-headed fruit bat, Buettikofer's epauletted fruit bat, the Egyptian fruit bat, the Jamaican fruit bat, the Mexican free-tailed bat and the big brown bat. In addition, we showed that Marburg virus Angola and Ebola virus Makona-WPGC07 efficiently replicated at 37°C, 37°-41°C, or 41°C, contrary to the hypothesis that temporal elevation in temperature due to flight affects filovirus replication in bats.
Medical subject headings
- Chiroptera
- Disease Reservoirs
- Filoviridae
- Filoviridae Infections
- Hemorrhagic Fever, Ebola
- Marburg Virus Disease